Assay Detail
Binding
CHEMBL4430049
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta in Balb/c mouse B cells assessed as reduction in anti-IgM induced CD86 expression preincubated for 1 hr followed by anti-IgM stimulation for 24 hrs by flow cytometry
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL2216745) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.07 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4588314 | — | — | 1 | 7.58 |
| CHEMBL3944013 | — | — | 1 | 7.47 |
| CHEMBL3947814 | — | — | 1 | 7.16 |
| CHEMBL3977066 | — | — | 1 | 7.16 |
| CHEMBL4453497 | — | — | 1 | 7.13 |
| CHEMBL4454454 | — | — | 1 | 7.07 |
| CHEMBL4467868 | — | — | 1 | 7.06 |
| CHEMBL4581278 | — | — | 1 | 7.06 |
| CHEMBL4521888 | — | — | 1 | 7.03 |
| CHEMBL4460621 | — | — | 1 | 6.95 |
| CHEMBL4437791 | — | — | 1 | 6.72 |
| CHEMBL4469006 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4588314 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3944013 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3947814 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3977066 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4453497 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4454454 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4467868 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4581278 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4521888 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4460621 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4437791 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4469006 | — | IC50 | = | 393.0 | nM | 6.41 |