Assay Detail
Binding
CHEMBL4430174
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Inhibition of HIV NL4.3 integrase T124/T125 double mutant assessed as reduction in viral replication by luciferase reporter gene assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 8.03 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4453654 | — | — | 1 | 8.96 |
| CHEMBL4545710 | — | — | 1 | 8.60 |
| CHEMBL4471774 | — | — | 1 | 8.52 |
| CHEMBL4448075 | — | — | 1 | 8.52 |
| CHEMBL4438126 | — | — | 1 | 8.52 |
| CHEMBL4450845 | — | — | 1 | 8.48 |
| CHEMBL4460351 | — | — | 1 | 8.43 |
| CHEMBL4556009 | — | — | 1 | 8.38 |
| CHEMBL4450648 | — | — | 1 | 8.36 |
| CHEMBL4543781 | — | — | 1 | 8.33 |
| CHEMBL4586462 | — | — | 1 | 8.33 |
| CHEMBL3287919 | — | — | 1 | 8.26 |
| CHEMBL4445165 | — | — | 1 | 8.17 |
| CHEMBL4463935 | — | — | 1 | 8.14 |
| CHEMBL4468038 | — | — | 1 | 8.13 |
| CHEMBL4472520 | — | — | 1 | 8.12 |
| CHEMBL3287925 | — | — | 1 | 8.11 |
| CHEMBL4556168 | — | — | 1 | 7.92 |
| CHEMBL4562716 | — | — | 1 | 7.85 |
| CHEMBL4438934 | — | — | 1 | 7.82 |
| CHEMBL4468349 | — | — | 1 | 7.80 |
| CHEMBL3259907 | BI-224436 | 1.0 | 1 | 7.72 |
| CHEMBL4572464 | — | — | 1 | 7.57 |
| CHEMBL4441150 | — | — | 1 | 6.03 |
| CHEMBL4553496 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4453654 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4545710 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4471774 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4448075 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4438126 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4450845 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4460351 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4556009 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4450648 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4543781 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4586462 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3287919 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4445165 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4463935 | — | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4468038 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4472520 | — | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL3287925 | — | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4556168 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4562716 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4438934 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4468349 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3259907 | BI-224436 | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4572464 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4441150 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4553496 | — | EC50 | = | 2200.0 | nM | 5.66 |