Assay Detail
Binding
CHEMBL4430175
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Inhibition of HIV NL4.3 integrase N124/T125 double mutant assessed as reduction in viral replication by luciferase reporter gene assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.60 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3259907 | BI-224436 | 1.0 | 1 | 7.52 |
| CHEMBL4450845 | — | — | 1 | 7.23 |
| CHEMBL4471774 | — | — | 1 | 7.04 |
| CHEMBL4448075 | — | — | 1 | 6.92 |
| CHEMBL4472520 | — | — | 1 | 6.89 |
| CHEMBL4545710 | — | — | 1 | 6.77 |
| CHEMBL4562716 | — | — | 1 | 6.70 |
| CHEMBL4468038 | — | — | 1 | 6.66 |
| CHEMBL4556009 | — | — | 1 | 6.66 |
| CHEMBL4572464 | — | — | 1 | 6.55 |
| CHEMBL4586462 | — | — | 1 | 6.51 |
| CHEMBL3287919 | — | — | 1 | 6.41 |
| CHEMBL4450648 | — | — | 1 | 6.25 |
| CHEMBL4463935 | — | — | 1 | 6.24 |
| CHEMBL4445165 | — | — | 1 | 6.22 |
| CHEMBL4556168 | — | — | 1 | 6.17 |
| CHEMBL3287925 | — | — | 1 | 6.09 |
| CHEMBL4438934 | — | — | 1 | 5.96 |
| CHEMBL4468349 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3259907 | BI-224436 | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4450845 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4471774 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4448075 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4472520 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4545710 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4562716 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4468038 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4556009 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4572464 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4586462 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3287919 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4450648 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4463935 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4445165 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4556168 | — | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3287925 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4438934 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4468349 | — | EC50 | > | 2500.0 | nM | - |