Assay Detail
Functional
CHEMBL4430209
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Cytotoxicity against erlotinib-resistant human HCC827B cells expressing MET assessed as reduction in cell viability after 72 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC827 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mitochondrial-Targeting MET Kinase Inhibitor Kills Erlotinib-Resistant Lung Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.17 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4534023 | — | — | 1 | 5.28 |
| CHEMBL450786 | PHA-665752 | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4534023 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL450786 | PHA-665752 | IC50 | = | 8900.0 | nM | 5.05 |