Assay Detail
Binding
CHEMBL4430334
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Displacement of [3H]spiperone from rat D3 dopamine receptor expressed in HEK293 cell membranes after 1 hr
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel multifunctional dopamine D<sub>2</sub>/D<sub>3</sub> receptors agonists with potential neuroprotection and anti-alpha synuclein protein aggregation properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 8.36 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4538230 | — | — | 1 | 9.31 |
| CHEMBL4535160 | — | — | 1 | 9.17 |
| CHEMBL4466245 | — | — | 1 | 9.11 |
| CHEMBL4442119 | — | — | 1 | 9.00 |
| CHEMBL4457171 | — | — | 1 | 8.85 |
| CHEMBL4452046 | — | — | 1 | 8.80 |
| CHEMBL273273 | 5-OH-DPAT | — | 1 | 8.68 |
| CHEMBL4581614 | — | — | 1 | 8.59 |
| CHEMBL4558954 | — | — | 1 | 8.44 |
| CHEMBL4456350 | — | — | 1 | 8.37 |
| CHEMBL4535068 | — | — | 1 | 7.92 |
| CHEMBL4549004 | — | — | 1 | 7.80 |
| CHEMBL4573578 | — | — | 1 | 7.65 |
| CHEMBL4442437 | — | — | 1 | 7.63 |
| CHEMBL4593758 | — | — | 1 | 7.41 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4538230 | — | Ki | = | 0.493 | nM | 9.31 |
| CHEMBL4535160 | — | Ki | = | 0.675 | nM | 9.17 |
| CHEMBL4466245 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL4442119 | — | Ki | = | 1.01 | nM | 9.00 |
| CHEMBL4457171 | — | Ki | = | 1.42 | nM | 8.85 |
| CHEMBL4452046 | — | Ki | = | 1.57 | nM | 8.80 |
| CHEMBL273273 | 5-OH-DPAT | Ki | = | 2.07 | nM | 8.68 |
| CHEMBL4581614 | — | Ki | = | 2.59 | nM | 8.59 |
| CHEMBL4558954 | — | Ki | = | 3.62 | nM | 8.44 |
| CHEMBL4456350 | — | Ki | = | 4.24 | nM | 8.37 |
| CHEMBL4535068 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL4549004 | — | Ki | = | 15.8 | nM | 7.80 |
| CHEMBL4573578 | — | Ki | = | 22.3 | nM | 7.65 |
| CHEMBL4442437 | — | Ki | = | 23.3 | nM | 7.63 |
| CHEMBL4593758 | — | Ki | = | 39.1 | nM | 7.41 |
| CHEMBL59 | DOPAMINE | Ki | = | 101.0 | nM | 7.00 |