Assay Detail
Functional
CHEMBL4430338
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Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel multifunctional dopamine D<sub>2</sub>/D<sub>3</sub> receptors agonists with potential neuroprotection and anti-alpha synuclein protein aggregation properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.65 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4538230 | — | — | 1 | 9.48 |
| CHEMBL4452046 | — | — | 1 | 9.11 |
| CHEMBL4466245 | — | — | 1 | 8.91 |
| CHEMBL4457171 | — | — | 1 | 8.58 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.14 |
| CHEMBL4573578 | — | — | 1 | 7.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4538230 | — | EC50 | = | 0.33 | nM | 9.48 |
| CHEMBL4452046 | — | EC50 | = | 0.78 | nM | 9.11 |
| CHEMBL4466245 | — | EC50 | = | 1.22 | nM | 8.91 |
| CHEMBL4457171 | — | EC50 | = | 2.62 | nM | 8.58 |
| CHEMBL59 | DOPAMINE | EC50 | = | 7.26 | nM | 8.14 |
| CHEMBL4573578 | — | EC50 | = | 20.4 | nM | 7.69 |