Assay Detail
Binding
CHEMBL4430365
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Inhibition of FLT3 (unknown origin)
22
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones as potent PLK4 inhibitors with oral antitumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.93 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4437872 | — | — | 1 | 7.77 |
| CHEMBL4579738 | — | — | 1 | 7.57 |
| CHEMBL4434704 | — | — | 1 | 7.55 |
| CHEMBL4553351 | — | — | 1 | 7.36 |
| CHEMBL4448596 | — | — | 1 | 7.35 |
| CHEMBL2407911 | — | — | 1 | 7.31 |
| CHEMBL4449539 | — | — | 1 | 7.30 |
| CHEMBL4440812 | — | — | 1 | 7.21 |
| CHEMBL4466113 | — | — | 1 | 7.14 |
| CHEMBL4470693 | — | — | 1 | 7.11 |
| CHEMBL4516793 | — | — | 2 | 7.01 |
| CHEMBL4475381 | — | — | 1 | 7.01 |
| CHEMBL4562664 | — | — | 1 | 6.92 |
| CHEMBL4546145 | — | — | 1 | 6.70 |
| CHEMBL4437913 | — | — | 1 | 6.70 |
| CHEMBL4440053 | — | — | 1 | 6.64 |
| CHEMBL4461353 | — | — | 1 | 6.62 |
| CHEMBL4457197 | — | — | 1 | 6.50 |
| CHEMBL4590185 | — | — | 1 | 5.92 |
| CHEMBL4467348 | — | — | 1 | 5.19 |
| CHEMBL4457259 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4437872 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4579738 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4434704 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4553351 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4448596 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2407911 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4449539 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4440812 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4466113 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4470693 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4516793 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4475381 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4562664 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4546145 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4437913 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4440053 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4461353 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4516793 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4457197 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4590185 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4467348 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4457259 | — | IC50 | - | — | - |