Assay Detail
Binding
CHEMBL4430367
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Inhibition of KDR (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones as potent PLK4 inhibitors with oral antitumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.33 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4434704 | — | — | 1 | 6.20 |
| CHEMBL4553351 | — | — | 1 | 5.25 |
| CHEMBL4448596 | — | — | 1 | 5.03 |
| CHEMBL4516793 | — | — | 1 | 4.85 |
| CHEMBL4440053 | — | — | 1 | - |
| CHEMBL4437913 | — | — | 1 | - |
| CHEMBL4440812 | — | — | 1 | - |
| CHEMBL4470693 | — | — | 1 | - |
| CHEMBL4467348 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4434704 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4553351 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4448596 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4516793 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4440053 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4437913 | — | IC50 | - | — | - | |
| CHEMBL4440812 | — | IC50 | - | — | - | |
| CHEMBL4470693 | — | IC50 | - | — | - | |
| CHEMBL4467348 | — | IC50 | > | 50000.0 | nM | - |