Assay Detail
Functional
CHEMBL4430764
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Cytotoxicity against human K562 cells after 72 hrs by CCK8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.06 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4524408 | — | — | 1 | 7.52 |
| CHEMBL4565346 | — | — | 1 | 7.52 |
| CHEMBL4525397 | — | — | 1 | 7.30 |
| CHEMBL4471846 | — | — | 1 | 7.30 |
| CHEMBL4469740 | — | — | 1 | 7.16 |
| CHEMBL2375780 | — | — | 1 | 7.16 |
| CHEMBL124518 | PHORBOL | — | 1 | 7.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4524408 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4565346 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4525397 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4471846 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4469740 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2375780 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL124518 | PHORBOL | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3210.0 | nM | 5.49 |