Assay Detail
Functional
CHEMBL4430765
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Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.11 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.72 |
| CHEMBL4525397 | — | — | 1 | 5.51 |
| CHEMBL4565346 | — | — | 1 | 5.20 |
| CHEMBL4524408 | — | — | 1 | 5.16 |
| CHEMBL2375780 | — | — | 1 | 5.07 |
| CHEMBL4469740 | — | — | 1 | 5.05 |
| CHEMBL124518 | PHORBOL | — | 1 | 4.82 |
| CHEMBL4471846 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL4525397 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL4565346 | — | IC50 | = | 6330.0 | nM | 5.20 |
| CHEMBL4524408 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL2375780 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4469740 | — | IC50 | = | 8860.0 | nM | 5.05 |
| CHEMBL124518 | PHORBOL | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL4471846 | — | IC50 | = | 43500.0 | nM | 4.36 |