Assay Detail
Binding
CHEMBL4430872
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Binding affinity to CB1 receptor (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB<sub>2</sub> receptor antagonists/inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.92 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL465 | DRONABINOL | 4.0 | 1 | 7.39 |
| CHEMBL15848 | ANANDAMIDE | — | 1 | 7.05 |
| CHEMBL122972 | 2-ARACHIDONOYLGLYCEROL | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL465 | DRONABINOL | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL15848 | ANANDAMIDE | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL122972 | 2-ARACHIDONOYLGLYCEROL | Ki | = | 472.0 | nM | 6.33 |