Assay Detail
Binding
CHEMBL4431146
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Inhibition of recombinant TDP1 (unknown origin) using 5'-32P-labeled N14Y DNA substrate incubated for 15 mins by PAGE analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.50 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464463 | — | — | 1 | 8.30 |
| CHEMBL4571632 | — | — | 1 | 7.66 |
| CHEMBL4465069 | — | — | 1 | 5.11 |
| CHEMBL4457160 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464463 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4571632 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4465069 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4457160 | — | IC50 | = | 12100.0 | nM | 4.92 |