Assay Detail
Binding
CHEMBL4431230
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Inhibition of LDHA in human MiPaca2 cells assessed as inhibition of lactate production
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.42 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4520899 | — | — | 1 | 6.17 |
| CHEMBL4065858 | — | — | 1 | 6.17 |
| CHEMBL4450897 | — | — | 1 | 5.54 |
| CHEMBL4534918 | — | — | 1 | 5.41 |
| CHEMBL4543949 | — | — | 1 | 5.29 |
| CHEMBL4475593 | — | — | 1 | 5.21 |
| CHEMBL4557701 | — | — | 1 | 5.00 |
| CHEMBL4583899 | — | — | 1 | 4.60 |
| CHEMBL4543194 | — | — | 1 | - |
| CHEMBL4536094 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4520899 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4065858 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4450897 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4534918 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4543949 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4475593 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4557701 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4583899 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4543194 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4536094 | — | IC50 | > | 50000.0 | nM | - |