Assay Detail

CHEMBL4431574

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to His-tagged Dengue virus 3 methyltransferase expressed in Escherichia coli Rosetta 2(DE3) by VP-ITC isothermal titration calorimetry

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	dengue virus type 3
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

The Medicinal Chemistry of Dengue Virus.

Behnam MA, Nitsche C, Boldescu V, Klein CD.
J Med Chem (2016) 59 : 5622 -5649
PubMed 26771861 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	6.48	6.87

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1214186	SINEFUNGIN	2.0	1	6.87
CHEMBL1088977	ADEMETIONINE	3.0	1	6.08

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1214186	SINEFUNGIN	Kd	=	136.0	nM	6.87
CHEMBL1088977	ADEMETIONINE	Kd	=	826.0	nM	6.08