Assay Detail
Binding
CHEMBL4431700
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation of gamma-secretase in CHO cells expressing human APP assessed as reduction in amyloid beta (1 to 42 residues) production after 24 hrs by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Gamma Secretase Modulators: New Alzheimer's Drugs on the Horizon?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.00 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3951810 | — | — | 1 | 8.10 |
| CHEMBL3980608 | — | — | 1 | 8.05 |
| CHEMBL3955146 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3951810 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3980608 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3955146 | — | EC50 | = | 14.0 | nM | 7.85 |