Assay Detail

CHEMBL4431706

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Cytotoxicity against human KB cells assessed as decrease in cell viability after 72 hrs by MTT assay

ChEMBL ↗

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Target

KB (CHEMBL398) ↗

Open DB target context

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Primary target KB

CHEMBL398

Anchored from Assay target.

Protein identity KB

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	KB
Confidence	1 — Organism
Curated By	Autocuration

Target

KB (CHEMBL398) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells.

Ordóñez PE, Sharma KK, Bystrom LM, Alas MA, Enriquez RG, Malagón O, Jones DE, Guzman ML, Compadre CM.
J Nat Prod (2016) 79 : 691 -696
PubMed 27057812 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.28	5.28

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL441260	DEHYDROLEUCODIN	—	1	5.28

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL441260	DEHYDROLEUCODIN	IC50	=	5300.0	nM	5.28