Assay Detail
Binding
CHEMBL4431937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SHP2 in human KYSE520 cells assessed as inhibition of ERK phosphorylation measured after 2 hrs by AlphaScreen assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 11 (CHEMBL3864) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.17 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4060033 | — | — | 1 | 6.60 |
| CHEMBL4540461 | — | — | 1 | 6.21 |
| CHEMBL4445214 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4060033 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4540461 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4445214 | — | IC50 | = | 1980.0 | nM | 5.70 |