Assay Detail
Binding
CHEMBL4431994
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Trypanosoma brucei PTR1 using H2B as substrate incubated for 10 mins followed by addition of NADPH measured for 10 to 50 mins
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.76 | 5.37 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464764 | — | — | 1 | 5.37 |
| CHEMBL294009 | FLAVONOL | — | 1 | 4.89 |
| CHEMBL379064 | ISORHAMNETIN | — | 1 | 4.86 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.55 |
| CHEMBL503168 | DATISCETIN | — | 1 | 4.11 |
| CHEMBL1520590 | — | — | 1 | - |
| CHEMBL1883743 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464764 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL294009 | FLAVONOL | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL379064 | ISORHAMNETIN | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL503168 | DATISCETIN | IC50 | = | 76900.0 | nM | 4.11 |
| CHEMBL1520590 | — | Inhibition | - | % | - | |
| CHEMBL1883743 | — | Inhibition | - | % | - |