Assay Detail
Binding
CHEMBL4432064
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Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and carbonic anhydrase inhibitory effects of new N-glycosylsulfonamides incorporating the phenol moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.70 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL224292 | — | — | 1 | 7.10 |
| CHEMBL4458516 | — | — | 1 | 6.86 |
| CHEMBL4454282 | — | — | 1 | 6.86 |
| CHEMBL4465817 | — | — | 1 | 6.85 |
| CHEMBL4443182 | — | — | 1 | 6.53 |
| CHEMBL4449836 | — | — | 1 | 6.47 |
| CHEMBL4469108 | — | — | 1 | 6.44 |
| CHEMBL4459557 | — | — | 1 | 6.16 |
| CHEMBL4565694 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL224292 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL4458516 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL4454282 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL4465817 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL4443182 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL4449836 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL4469108 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL4459557 | — | Ki | = | 695.0 | nM | 6.16 |
| CHEMBL4565694 | — | Ki | = | 1680.0 | nM | 5.78 |