Assay Detail
Binding
CHEMBL4432067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DPP4 (39 to 766 residues) using Ala-Pro-AFC as substrate incubated for 1 hr by fluorescence assay
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.50 | 9.00 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237500 | LINAGLIPTIN | 4.0 | 1 | 9.00 |
| CHEMBL237067 | — | — | 1 | 8.30 |
| CHEMBL376359 | ALOGLIPTIN | 4.0 | 1 | 8.15 |
| CHEMBL399216 | — | — | 1 | 7.09 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 7.02 |
| CHEMBL4456228 | — | — | 1 | 5.41 |
| CHEMBL2147777 | TENELIGLIPTIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237500 | LINAGLIPTIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL237067 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL376359 | ALOGLIPTIN | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL399216 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4456228 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2147777 | TENELIGLIPTIN | Inhibition | - | % | - |