Assay Detail
Functional
CHEMBL4432235
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Agonist activity at human CB1R expressed in CHO cells by Ca2+ flux assay
18
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Peripherally Selective Cannabinoid 1 Receptor (CB1R) Agonists for the Treatment of Neuropathic Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.77 | 6.98 |
| Emax | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4516360 | — | — | 2 | 6.98 |
| CHEMBL4483714 | — | — | 2 | 6.85 |
| CHEMBL4443660 | — | — | 2 | 6.74 |
| CHEMBL123515 | — | — | 2 | 6.71 |
| CHEMBL127644 | — | — | 2 | 6.59 |
| CHEMBL4438072 | — | — | 2 | - |
| CHEMBL4519883 | — | — | 2 | - |
| CHEMBL4435655 | — | — | 2 | - |
| CHEMBL4550629 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4516360 | — | EC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4483714 | — | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL4443660 | — | EC50 | = | 182.0 | nM | 6.74 |
| CHEMBL123515 | — | EC50 | = | 196.0 | nM | 6.71 |
| CHEMBL127644 | — | EC50 | = | 257.0 | nM | 6.59 |
| CHEMBL4519883 | — | EC50 | - | — | - | |
| CHEMBL4435655 | — | EC50 | - | — | - | |
| CHEMBL4550629 | — | EC50 | - | — | - | |
| CHEMBL4438072 | — | EC50 | - | — | - | |
| CHEMBL4519883 | — | Emax | - | — | - | |
| CHEMBL4435655 | — | Emax | - | — | - | |
| CHEMBL4516360 | — | Emax | = | 79.0 | % | - |
| CHEMBL127644 | — | Emax | = | 103.0 | % | - |
| CHEMBL123515 | — | Emax | = | 114.0 | % | - |
| CHEMBL4550629 | — | Emax | - | — | - | |
| CHEMBL4483714 | — | Emax | = | 121.0 | % | - |
| CHEMBL4443660 | — | Emax | = | 108.0 | % | - |
| CHEMBL4438072 | — | Emax | - | — | - |