Assay Detail
Functional
CHEMBL4432349
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of glucagon receptor (unknown origin) transfected in HEK293 cells coinfected with luciferase reporter gene linked CRE element assessed as cAMP accumulation after 5 hrs in presence of luclite substrate by liquid scintillation counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 10.28 | 10.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4453136 | — | — | 1 | 10.77 |
| CHEMBL5314341 | GLUCAGON | 4.0 | 1 | 10.67 |
| CHEMBL4469604 | — | — | 1 | 10.57 |
| CHEMBL4466715 | — | — | 1 | 10.51 |
| CHEMBL4571762 | — | — | 1 | 10.47 |
| CHEMBL4458230 | — | — | 1 | 10.44 |
| CHEMBL4586269 | — | — | 1 | 10.42 |
| CHEMBL4578443 | — | — | 1 | 10.40 |
| CHEMBL4444485 | — | — | 1 | 10.15 |
| CHEMBL4437733 | — | — | 1 | 10.07 |
| CHEMBL4466856 | — | — | 1 | 8.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4453136 | — | EC50 | = | 0.017 | nM | 10.77 |
| CHEMBL5314341 | GLUCAGON | EC50 | = | 0.0212 | nM | 10.67 |
| CHEMBL4469604 | — | EC50 | = | 0.0268 | nM | 10.57 |
| CHEMBL4466715 | — | EC50 | = | 0.0309 | nM | 10.51 |
| CHEMBL4571762 | — | EC50 | = | 0.0339 | nM | 10.47 |
| CHEMBL4458230 | — | EC50 | = | 0.0359 | nM | 10.44 |
| CHEMBL4586269 | — | EC50 | = | 0.0379 | nM | 10.42 |
| CHEMBL4578443 | — | EC50 | = | 0.0399 | nM | 10.40 |
| CHEMBL4444485 | — | EC50 | = | 0.0714 | nM | 10.15 |
| CHEMBL4437733 | — | EC50 | = | 0.0843 | nM | 10.07 |
| CHEMBL4466856 | — | EC50 | = | 2.325 | nM | 8.63 |