Assay Detail
Functional
CHEMBL4432407
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Antiviral activity against HCV assessed as inhibition of viral RNA replication in replicon cells by luciferase reporter gene assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 35 | 6.88 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4444480 | — | — | 1 | 9.52 |
| CHEMBL4441238 | — | — | 1 | 9.40 |
| CHEMBL4527971 | — | — | 1 | 9.30 |
| CHEMBL4451988 | — | — | 1 | 9.15 |
| CHEMBL4463284 | — | — | 1 | 9.15 |
| CHEMBL4593826 | — | — | 1 | 9.10 |
| CHEMBL4545438 | — | — | 1 | 9.00 |
| CHEMBL4464159 | — | — | 1 | 8.77 |
| CHEMBL4567705 | — | — | 1 | 8.32 |
| CHEMBL4471005 | — | — | 1 | 8.25 |
| CHEMBL4548240 | — | — | 1 | 7.75 |
| CHEMBL4522572 | — | — | 1 | 7.63 |
| CHEMBL4434914 | — | — | 1 | 6.50 |
| CHEMBL561360 | — | — | 1 | 6.43 |
| CHEMBL4464724 | — | — | 1 | 6.18 |
| CHEMBL4441399 | — | — | 1 | 5.81 |
| CHEMBL4575406 | — | — | 1 | 5.67 |
| CHEMBL4448379 | — | — | 1 | 5.64 |
| CHEMBL4454342 | — | — | 1 | 5.62 |
| CHEMBL4563132 | — | — | 1 | 5.61 |
| CHEMBL4584994 | — | — | 1 | 5.58 |
| CHEMBL4541419 | — | — | 1 | 5.57 |
| CHEMBL4463960 | — | — | 1 | 5.57 |
| CHEMBL4578396 | — | — | 1 | 5.55 |
| CHEMBL4459000 | — | — | 1 | 5.54 |
| CHEMBL4529821 | — | — | 1 | 5.52 |
| CHEMBL4474860 | — | — | 1 | 5.47 |
| CHEMBL4465164 | — | — | 1 | 5.45 |
| CHEMBL4567123 | — | — | 1 | 5.45 |
| CHEMBL4533843 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4444480 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4441238 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4527971 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4451988 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4463284 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4593826 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4545438 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4464159 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4567705 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4471005 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4548240 | — | EC50 | = | 17.8 | nM | 7.75 |
| CHEMBL4522572 | — | EC50 | = | 23.2 | nM | 7.63 |
| CHEMBL4434914 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL561360 | — | EC50 | = | 369.0 | nM | 6.43 |
| CHEMBL4464724 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4441399 | — | EC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4575406 | — | EC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL4448379 | — | EC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL4454342 | — | EC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL4563132 | — | EC50 | = | 2471.2 | nM | 5.61 |
| CHEMBL4584994 | — | EC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL4541419 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4463960 | — | EC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL4578396 | — | EC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL4459000 | — | EC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL4529821 | — | EC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL4474860 | — | EC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL4465164 | — | EC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL4567123 | — | EC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL4533843 | — | EC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL167790 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4557948 | — | EC50 | > | 8300.0 | nM | - |
| CHEMBL4573414 | — | EC50 | > | 8300.0 | nM | - |
| CHEMBL4445547 | — | EC50 | > | 8300.0 | nM | - |
| CHEMBL4552559 | — | EC50 | > | 8300.0 | nM | - |