Assay Detail
Binding
CHEMBL4432408
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Inhibition of HCV genotype 1b J4 NS5B RNA dependent RNA polymerase
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus isolate HC-J4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Genome polyprotein (CHEMBL3638332) ↗| Type | SINGLE PROTEIN |
| Organism | Hepatitis C virus genotype 1b (strain HC-J4) (HCV) |
Publication
Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.09 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4527971 | — | — | 1 | 8.29 |
| CHEMBL4463284 | — | — | 1 | 8.27 |
| CHEMBL4464159 | — | — | 1 | 8.25 |
| CHEMBL4451988 | — | — | 1 | 8.11 |
| CHEMBL4567705 | — | — | 1 | 8.04 |
| CHEMBL4522572 | — | — | 1 | 7.79 |
| CHEMBL4464724 | — | — | 1 | 7.68 |
| CHEMBL4441399 | — | — | 1 | 7.58 |
| CHEMBL561360 | — | — | 1 | 7.46 |
| CHEMBL4563132 | — | — | 1 | 7.34 |
| CHEMBL4578396 | — | — | 1 | 7.23 |
| CHEMBL4459000 | — | — | 1 | 7.09 |
| CHEMBL4575406 | — | — | 1 | 6.93 |
| CHEMBL4584994 | — | — | 1 | 6.87 |
| CHEMBL4567123 | — | — | 1 | 6.83 |
| CHEMBL4434914 | — | — | 1 | 6.81 |
| CHEMBL4463960 | — | — | 1 | 6.77 |
| CHEMBL4448379 | — | — | 1 | 6.72 |
| CHEMBL4529821 | — | — | 1 | 6.65 |
| CHEMBL4465164 | — | — | 1 | 6.53 |
| CHEMBL4474860 | — | — | 1 | 6.53 |
| CHEMBL4454342 | — | — | 1 | 6.50 |
| CHEMBL4541419 | — | — | 1 | 6.37 |
| CHEMBL4533843 | — | — | 1 | 6.29 |
| CHEMBL4573414 | — | — | 1 | 5.95 |
| CHEMBL4445547 | — | — | 1 | 5.43 |
| CHEMBL4557948 | — | — | 1 | - |
| CHEMBL4552559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4527971 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4463284 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4464159 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4451988 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4567705 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4522572 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL4464724 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4441399 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL561360 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4563132 | — | IC50 | = | 45.8 | nM | 7.34 |
| CHEMBL4578396 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4459000 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4575406 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL4584994 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL4567123 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL4434914 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL4463960 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4448379 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL4529821 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL4465164 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL4474860 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL4454342 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL4541419 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL4533843 | — | IC50 | = | 517.0 | nM | 6.29 |
| CHEMBL4573414 | — | IC50 | = | 1126.0 | nM | 5.95 |
| CHEMBL4445547 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL4557948 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL4552559 | — | IC50 | > | 10000.0 | nM | - |