Assay Detail
Binding
CHEMBL4432409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HCV genotype 1b Con1 NS5B RNA dependent RNA polymerase
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus (isolate Con1) |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Genome polyprotein (CHEMBL5536) ↗| Type | SINGLE PROTEIN |
| Organism | Hepatitis C virus genotype 1b (isolate Con1) (HCV) |
Publication
Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.79 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4527971 | — | — | 1 | 8.05 |
| CHEMBL4441238 | — | — | 3 | 8.00 |
| CHEMBL4444480 | — | — | 1 | 7.84 |
| CHEMBL4545438 | — | — | 1 | 7.79 |
| CHEMBL4593826 | — | — | 1 | 7.75 |
| CHEMBL4471005 | — | — | 1 | 7.60 |
| CHEMBL4548240 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4527971 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4441238 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4441238 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL4444480 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL4545438 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL4593826 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4441238 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL4471005 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL4548240 | — | IC50 | = | 33.5 | nM | 7.47 |