Assay Detail
Binding
CHEMBL4432412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HCV genotype 4a1 NS5B RNA dependent RNA polymerase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.12 | 7.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4444480 | — | — | 1 | 7.61 |
| CHEMBL4441238 | — | — | 1 | 7.59 |
| CHEMBL4593826 | — | — | 1 | 7.29 |
| CHEMBL4545438 | — | — | 1 | 7.12 |
| CHEMBL4471005 | — | — | 1 | 6.71 |
| CHEMBL4548240 | — | — | 1 | 6.37 |
| CHEMBL4527971 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4444480 | — | IC50 | = | 24.4 | nM | 7.61 |
| CHEMBL4441238 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL4593826 | — | IC50 | = | 51.7 | nM | 7.29 |
| CHEMBL4545438 | — | IC50 | = | 75.3 | nM | 7.12 |
| CHEMBL4471005 | — | IC50 | = | 196.6 | nM | 6.71 |
| CHEMBL4548240 | — | IC50 | = | 430.8 | nM | 6.37 |
| CHEMBL4527971 | — | IC50 | - | — | - |