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Assay Detail

CHEMBL4432426

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of LSD1 (unknown origin)
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Lysine-specific histone demethylase 1A (CHEMBL6136)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of novel (E)-N'-(2,3-dihydro-1H-inden-1-ylidene) benzohydrazides as potent LSD1 inhibitors.
Zhou Y, Li Y, Wang WJ, Xiang P, Luo XM, Yang L, Yang SY, Zhao YL.
Bioorg Med Chem Lett (2016) 26 : 4552 -4557
PubMed 27524309 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 62 8.07 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4436953 1 8.85
CHEMBL4454677 1 8.77
CHEMBL4549707 1 8.64
CHEMBL4546158 1 8.34
CHEMBL4588399 1 8.31
CHEMBL4540594 1 8.04
CHEMBL4547521 1 5.54
CHEMBL4559543 1 -
CHEMBL4593841 1 -
CHEMBL4541896 1 -
CHEMBL4475967 1 -
CHEMBL4474154 1 -
CHEMBL4449056 1 -
CHEMBL4471455 1 -
CHEMBL4576643 1 -
CHEMBL4462074 1 -
CHEMBL4566191 1 -
CHEMBL4569097 1 -
CHEMBL4449534 1 -
CHEMBL4565576 1 -
CHEMBL4460485 1 -
CHEMBL4461352 1 -
CHEMBL4462733 1 -
CHEMBL4457794 1 -
CHEMBL4557550 1 -
CHEMBL4528729 1 -
CHEMBL4590800 1 -
CHEMBL4576035 1 -
CHEMBL4463891 1 -
CHEMBL4471546 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4436953 IC50 = 1.4 nM 8.85
CHEMBL4454677 IC50 = 1.7 nM 8.77
CHEMBL4549707 IC50 = 2.3 nM 8.64
CHEMBL4546158 IC50 = 4.6 nM 8.34
CHEMBL4588399 IC50 = 4.9 nM 8.31
CHEMBL4540594 IC50 = 9.2 nM 8.04
CHEMBL4547521 IC50 = 2900.0 nM 5.54
CHEMBL4456993 IC50 > 100000.0 nM -
CHEMBL4593841 IC50 > 100000.0 nM -
CHEMBL4558723 IC50 > 100000.0 nM -
CHEMBL4516207 IC50 > 50000.0 nM -
CHEMBL4458759 IC50 > 100000.0 nM -
CHEMBL4474193 IC50 > 50000.0 nM -
CHEMBL4475427 IC50 > 50000.0 nM -
CHEMBL4575332 IC50 > 100000.0 nM -
CHEMBL4568420 IC50 > 100000.0 nM -
CHEMBL4544926 IC50 > 100000.0 nM -
CHEMBL4525326 IC50 > 50000.0 nM -
CHEMBL4527148 IC50 > 100000.0 nM -
CHEMBL4442609 IC50 > 10000.0 nM -
CHEMBL4574308 IC50 > 100000.0 nM -
CHEMBL4468660 IC50 > 10000.0 nM -
CHEMBL4571102 IC50 > 100000.0 nM -
CHEMBL4538258 IC50 > 10000.0 nM -
CHEMBL4437393 IC50 > 100000.0 nM -
CHEMBL4439411 IC50 > 100000.0 nM -
CHEMBL4550208 IC50 > 100000.0 nM -
CHEMBL4437553 IC50 > 100000.0 nM -
CHEMBL4565576 IC50 > 100000.0 nM -
CHEMBL4471546 IC50 > 100000.0 nM -
CHEMBL4463891 IC50 > 100000.0 nM -
CHEMBL4576035 IC50 > 50000.0 nM -
CHEMBL4590800 IC50 > 100000.0 nM -
CHEMBL4528729 IC50 > 100000.0 nM -
CHEMBL4557550 IC50 > 100000.0 nM -
CHEMBL4457794 IC50 > 100000.0 nM -
CHEMBL4462733 IC50 > 100000.0 nM -
CHEMBL4461352 IC50 > 100000.0 nM -
CHEMBL4460485 IC50 > 100000.0 nM -
CHEMBL4569097 IC50 > 100000.0 nM -
CHEMBL4449534 IC50 > 100000.0 nM -
CHEMBL4559543 IC50 > 100000.0 nM -
CHEMBL4541896 IC50 > 100000.0 nM -
CHEMBL4475967 IC50 > 100000.0 nM -
CHEMBL4474154 IC50 > 50000.0 nM -
CHEMBL4449056 IC50 > 100000.0 nM -
CHEMBL4471455 IC50 > 100000.0 nM -
CHEMBL4576643 IC50 > 100000.0 nM -
CHEMBL4462074 IC50 > 100000.0 nM -
CHEMBL4566191 IC50 > 100000.0 nM -