Assay Detail
Binding
CHEMBL4432469
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]dofetilide binding to human ERG expressed in HEK293 cell membranes after 60 mins by liquid scintillation spectrometric analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.03 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122425 | — | — | 1 | 6.62 |
| CHEMBL4443407 | — | — | 1 | 5.99 |
| CHEMBL4442303 | — | — | 1 | 5.97 |
| CHEMBL4519939 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122425 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL4443407 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL4442303 | — | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL4519939 | — | Ki | = | 2940.0 | nM | 5.53 |