Assay Detail
Binding
CHEMBL4432676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of protease activity of Clostridium botulinum BoNT/A using SNAP-25 as substrate by FRET analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridium botulinum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Botulinum neurotoxin type A (CHEMBL5192) ↗| Type | SINGLE PROTEIN |
| Organism | Clostridium botulinum |
Publication
Identification of small molecule inhibitors of botulinum neurotoxin serotype E via footprint similarity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.61 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237370 | CINNAMIC ACID HYDROXAMATE | — | 1 | 6.39 |
| CHEMBL1232971 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237370 | CINNAMIC ACID HYDROXAMATE | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1232971 | — | IC50 | = | 15000.0 | nM | 4.82 |