Assay Detail
Binding
CHEMBL4432791
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PARP-2 (unknown origin) after 1 hr in presence of NAD+/biotinylated NAD+/slDNA by ELISA
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.28 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506871 | VELIPARIB | 3.0 | 1 | 8.89 |
| CHEMBL4522170 | — | — | 1 | 8.26 |
| CHEMBL4458889 | — | — | 1 | 8.14 |
| CHEMBL4435879 | — | — | 1 | 8.11 |
| CHEMBL4460350 | — | — | 1 | 8.00 |
| CHEMBL4592544 | — | — | 1 | - |
| CHEMBL4570886 | — | — | 1 | - |
| CHEMBL4458372 | — | — | 1 | - |
| CHEMBL4468323 | — | — | 1 | - |
| CHEMBL4436157 | — | — | 1 | - |
| CHEMBL4532640 | — | — | 1 | - |
| CHEMBL4578024 | — | — | 1 | - |
| CHEMBL4586369 | — | — | 1 | - |
| CHEMBL4515565 | — | — | 1 | - |
| CHEMBL4454541 | — | — | 1 | - |
| CHEMBL4463611 | — | — | 1 | - |
| CHEMBL4590570 | — | — | 1 | - |
| CHEMBL4447860 | — | — | 1 | - |
| CHEMBL4454690 | — | — | 1 | - |
| CHEMBL4459573 | — | — | 1 | - |
| CHEMBL4545981 | — | — | 1 | - |
| CHEMBL4563153 | — | — | 1 | - |
| CHEMBL4579910 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506871 | VELIPARIB | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4522170 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4458889 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4435879 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4460350 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4592544 | — | IC50 | - | — | - | |
| CHEMBL4570886 | — | IC50 | - | — | - | |
| CHEMBL4458372 | — | IC50 | - | — | - | |
| CHEMBL4468323 | — | IC50 | - | — | - | |
| CHEMBL4436157 | — | IC50 | - | — | - | |
| CHEMBL4532640 | — | IC50 | - | — | - | |
| CHEMBL4578024 | — | IC50 | - | — | - | |
| CHEMBL4586369 | — | IC50 | - | — | - | |
| CHEMBL4515565 | — | IC50 | - | — | - | |
| CHEMBL4454541 | — | IC50 | - | — | - | |
| CHEMBL4463611 | — | IC50 | - | — | - | |
| CHEMBL4590570 | — | IC50 | - | — | - | |
| CHEMBL4447860 | — | IC50 | - | — | - | |
| CHEMBL4454690 | — | IC50 | - | — | - | |
| CHEMBL4459573 | — | IC50 | - | — | - | |
| CHEMBL4545981 | — | IC50 | - | — | - | |
| CHEMBL4563153 | — | IC50 | - | — | - | |
| CHEMBL4579910 | — | IC50 | - | — | - |