Assay Detail
Functional
CHEMBL4432795
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Growth inhibition of human MDA-MB-468 cells after 72 hrs by SRB assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.51 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4460350 | — | — | 1 | 5.34 |
| CHEMBL4435879 | — | — | 1 | 4.72 |
| CHEMBL506871 | VELIPARIB | 3.0 | 1 | 4.37 |
| CHEMBL4458889 | — | — | 1 | 4.09 |
| CHEMBL4522170 | — | — | 1 | 4.03 |
| CHEMBL4447860 | — | — | 1 | - |
| CHEMBL4590570 | — | — | 1 | - |
| CHEMBL4454541 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4460350 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4435879 | — | EC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL506871 | VELIPARIB | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4458889 | — | EC50 | = | 81400.0 | nM | 4.09 |
| CHEMBL4522170 | — | EC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL4447860 | — | EC50 | - | — | - | |
| CHEMBL4590570 | — | EC50 | - | — | - | |
| CHEMBL4454541 | — | EC50 | - | — | - |