Assay Detail
Binding
CHEMBL4433000
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Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells preincubated for 10 mins followed by addition of kynuramine as substrate
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.16 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.31 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 5.41 |
| CHEMBL4520128 | — | — | 1 | 4.74 |
| CHEMBL4446827 | — | — | 1 | 4.69 |
| CHEMBL242341 | FORMONONETIN | 2.0 | 1 | 4.51 |
| CHEMBL376915 | — | — | 1 | 4.41 |
| CHEMBL334918 | MAACKIAIN | — | 1 | 4.07 |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | - |
| CHEMBL4579018 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL44 | GENISTEIN | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4520128 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL4446827 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL242341 | FORMONONETIN | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL376915 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL334918 | MAACKIAIN | IC50 | = | 85800.0 | nM | 4.07 |
| CHEMBL673 | PARGYLINE | IC50 | > | 2000.0 | nM | - |
| CHEMBL4579018 | — | IC50 | > | 100000.0 | nM | - |