Assay Detail
Binding
CHEMBL4433109
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Inhibition of Keap1 Kelch domain/FITC-9mer Nrf2 (unknown origin) interaction after 30 mins by fluorescence polarization assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Polar Recognition Group Study of Keap1-Nrf2 Protein-Protein Interaction Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.87 | 7.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601212 | — | — | 1 | 7.87 |
| CHEMBL4544116 | — | — | 1 | 7.80 |
| CHEMBL4515723 | — | — | 1 | 6.21 |
| CHEMBL4455786 | — | — | 1 | 5.58 |
| CHEMBL4592064 | — | — | 1 | - |
| CHEMBL4540101 | — | — | 1 | - |
| CHEMBL4546347 | — | — | 1 | - |
| CHEMBL4587926 | — | — | 1 | - |
| CHEMBL4469585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601212 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL4544116 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL4515723 | — | IC50 | = | 609.0 | nM | 6.21 |
| CHEMBL4455786 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4592064 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4540101 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4546347 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4587926 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4469585 | — | IC50 | > | 50000.0 | nM | - |