Assay Detail
Binding
CHEMBL4433137
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Binding affinity to 6His-tagged EphA4 C204A mutant (29 to 104 residues) (unknown origin) expressed in Escherichia coli Origami 2 (DE3) by isothermal titration calorimetry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.54 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4530593 | — | — | 1 | 7.72 |
| CHEMBL4464968 | — | — | 1 | 7.57 |
| CHEMBL4436732 | — | — | 1 | 7.52 |
| CHEMBL4449863 | — | — | 1 | 7.35 |
| CHEMBL4462106 | — | — | 1 | - |
| CHEMBL4464855 | — | — | 1 | - |
| CHEMBL4468291 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4530593 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL4464968 | — | Kd | = | 27.0 | nM | 7.57 |
| CHEMBL4436732 | — | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL4449863 | — | Kd | = | 45.0 | nM | 7.35 |
| CHEMBL4462106 | — | Kd | - | — | - | |
| CHEMBL4464855 | — | Kd | - | — | - | |
| CHEMBL4468291 | — | Kd | - | — | - |