Assay Detail
Binding
CHEMBL4433158
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human 6His-tagged PAD1 assessed as reduction in residual activity preincubated for 15 mins followed by addition of N-benzoylated arginine ethyl ester hydrochloride measured after 15 mins by colder assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein-arginine deiminase type-1 (CHEMBL1909486) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cellular Activity of New Small Molecule Protein Arginine Deiminase 3 (PAD3) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.28 | 4.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4468883 | — | — | 1 | 4.47 |
| CHEMBL4461562 | — | — | 1 | 4.28 |
| CHEMBL4464539 | — | — | 1 | 4.10 |
| CHEMBL4547728 | — | — | 1 | - |
| CHEMBL4449566 | — | — | 1 | - |
| CHEMBL4546087 | — | — | 1 | - |
| CHEMBL4473416 | — | — | 1 | - |
| CHEMBL4442207 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4468883 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4461562 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL4464539 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL4547728 | — | IC50 | = | 294000.0 | nM | - |
| CHEMBL4449566 | — | IC50 | = | 161000.0 | nM | - |
| CHEMBL4546087 | — | IC50 | = | 408000.0 | nM | - |
| CHEMBL4473416 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL4442207 | — | IC50 | > | 500000.0 | nM | - |