Assay Detail
Binding
CHEMBL4433282
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Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 mins
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H<sub>3</sub> receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.60 | 7.14 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1305 | ANTAZOLINE | 4.0 | 1 | 7.14 |
| CHEMBL4540849 | — | — | 2 | 6.53 |
| CHEMBL4586133 | — | — | 2 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1305 | ANTAZOLINE | Kd | = | 72.44 | nM | 7.14 |
| CHEMBL4540849 | — | Kd | = | 295.12 | nM | 6.53 |
| CHEMBL4586133 | — | Kd | = | 724.44 | nM | 6.14 |
| CHEMBL4540849 | — | Activity | - | — | - | |
| CHEMBL4586133 | — | Activity | - | — | - |