Assay Detail
Binding
CHEMBL4433367
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Inhibition of Pseudomonas aeruginosa IMPDH using IMP as substrate in the presence of NAD+ incubated for 70 secs
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Inosine-5'-monophosphate dehydrogenase (CHEMBL4523953) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Publication
First-in-class allosteric inhibitors of bacterial IMPDHs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.16 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.05 |
| CHEMBL296966 | CHICAGO SKY BLUE SODIUM | — | 1 | 5.80 |
| CHEMBL4573244 | — | — | 1 | 5.58 |
| CHEMBL4524330 | — | — | 1 | 5.55 |
| CHEMBL4577084 | — | — | 1 | 5.51 |
| CHEMBL4586403 | — | — | 1 | 5.40 |
| CHEMBL4581243 | — | — | 1 | 5.40 |
| CHEMBL4459529 | — | — | 1 | 5.16 |
| CHEMBL4588651 | — | — | 1 | 5.13 |
| CHEMBL4568025 | — | — | 1 | 4.93 |
| CHEMBL4515631 | — | — | 1 | 4.93 |
| CHEMBL4575154 | — | — | 1 | 4.77 |
| CHEMBL4442155 | — | — | 1 | 4.74 |
| CHEMBL4561888 | — | — | 1 | 4.72 |
| CHEMBL4551062 | — | — | 1 | 4.64 |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 1 | 4.26 |
| CHEMBL4582298 | — | — | 1 | - |
| CHEMBL4447222 | — | — | 1 | - |
| CHEMBL4462217 | — | — | 1 | - |
| CHEMBL4434987 | — | — | 1 | - |
| CHEMBL4520086 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51483 | GOSSYPOL | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL296966 | CHICAGO SKY BLUE SODIUM | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4573244 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4524330 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4577084 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4586403 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4581243 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4459529 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4588651 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4568025 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4515631 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4575154 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4442155 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL4561888 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4551062 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL4582298 | — | IC50 | - | — | - | |
| CHEMBL4447222 | — | IC50 | - | — | - | |
| CHEMBL4462217 | — | IC50 | - | — | - | |
| CHEMBL4434987 | — | IC50 | - | — | - | |
| CHEMBL4520086 | — | IC50 | - | — | - |