Assay Detail
Binding
CHEMBL4433375
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of chymotrypsin-like activity of human 26S proteasome in human Jurkat cells assessed as decrease in AMC hydrolysis using Z-Gly-Gly-Leu-AMC as substrate after 24 hrs by fluorescence based method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.24 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28 | APIGENIN | — | 1 | 6.00 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.89 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.70 |
| CHEMBL117 | CHRYSIN | — | 1 | 5.21 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.96 |
| CHEMBL164 | MYRICETIN | — | 1 | 4.92 |
| CHEMBL8996 | ERIODICTYOL | — | 1 | 4.84 |
| CHEMBL9352 | NARINGENIN | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28 | APIGENIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL50 | QUERCETIN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL117 | CHRYSIN | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL164 | MYRICETIN | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL8996 | ERIODICTYOL | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL9352 | NARINGENIN | IC50 | = | 41600.0 | nM | 4.38 |