Assay Detail
Binding
CHEMBL4433382
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of chymotrypsin-like activity of purified human 20S proteasome assessed as decrease in AMC hydrolysis using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 30 mins by fluorometric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.86 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 7.07 |
| CHEMBL129451 | (-)-CATECHINGALLATE | — | 1 | 6.91 |
| CHEMBL264938 | GALLOCATECHIN GALLATE | — | 1 | 6.73 |
| CHEMBL36327 | EPICATECHIN GALLATE | — | 1 | 6.71 |
| CHEMBL47386 | EPIGALLOCATECHIN | — | 1 | - |
| CHEMBL288114 | GALLIC ACID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL129451 | (-)-CATECHINGALLATE | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL264938 | GALLOCATECHIN GALLATE | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL36327 | EPICATECHIN GALLATE | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL47386 | EPIGALLOCATECHIN | IC50 | = | 1200000.0 | nM | - |
| CHEMBL288114 | GALLIC ACID | IC50 | = | 7100000.0 | nM | - |