Assay Detail
Binding
CHEMBL4433385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of chymotrypsin-like activity of purified human erythrocyte 20S proteasome assessed as decrease in AMC hydrolysis using Suc-LLVY-AMC as substrate preincubated for 10 mins and measured by fluorescence based method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.21 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129795 | ISOLIQUIRITIGENIN | — | 1 | 5.31 |
| CHEMBL402744 | — | — | 1 | 5.28 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 5.03 |
| CHEMBL252642 | LIQUIRTIGENIN | — | 1 | - |
| CHEMBL238845 | — | — | 1 | - |
| CHEMBL8145 | DAIDZEIN | 2.0 | 1 | - |
| CHEMBL242341 | FORMONONETIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129795 | ISOLIQUIRITIGENIN | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL402744 | — | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL44 | GENISTEIN | IC50 | = | 9260.0 | nM | 5.03 |
| CHEMBL252642 | LIQUIRTIGENIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL238845 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL8145 | DAIDZEIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL242341 | FORMONONETIN | IC50 | > | 100000.0 | nM | - |