Assay Detail
Binding
CHEMBL4433654
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus infected Sf6 insect cells using tertbutyloxycarbonyl (Boc)-(Ac)-Lys-7-amino-4-methylcoumarin as substrate incubated for 1 hr by fluorescence based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.32 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4590543 | — | — | 1 | 5.65 |
| CHEMBL4443876 | — | — | 1 | 5.43 |
| CHEMBL4575045 | — | — | 1 | 5.30 |
| CHEMBL4449010 | — | — | 1 | 4.89 |
| CHEMBL322970 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4590543 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL4443876 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL4575045 | — | IC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL4449010 | — | IC50 | = | 12780.0 | nM | 4.89 |
| CHEMBL322970 | — | IC50 | - | — | - |