Assay Detail
Functional
CHEMBL4433969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at D2R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gi-cAMP Glosensor assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 9.00 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 9.10 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.89 |
| CHEMBL353335 | — | — | 1 | - |
| CHEMBL4453318 | — | — | 1 | - |
| CHEMBL3697578 | RAZPIPADON | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59 | DOPAMINE | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL240773 | QUINPIROLE | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL353335 | — | EC50 | - | — | - | |
| CHEMBL4453318 | — | EC50 | - | — | - | |
| CHEMBL3697578 | RAZPIPADON | EC50 | - | — | - |