Assay Detail
Binding
CHEMBL4434136
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Agonist activity at human RXRalpha expressed in African green monkey COS1 cells harboring CRBP2-tk-luc reporter incubated for 18 hrs by steady-glo luciferase reporter gene assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3H-Imidazo[4,5-b]pyridine-6-carboxylic acid derivatives as rexinoids with reduced teratogenicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.30 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2332887 | — | — | 1 | 7.82 |
| CHEMBL1023 | BEXAROTENE | 4.0 | 1 | 7.70 |
| CHEMBL4465555 | — | — | 1 | 7.57 |
| CHEMBL2146901 | — | — | 1 | 6.84 |
| CHEMBL4546707 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2332887 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1023 | BEXAROTENE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4465555 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2146901 | — | EC50 | = | 143.0 | nM | 6.84 |
| CHEMBL4546707 | — | EC50 | = | 275.0 | nM | 6.56 |