Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4434141

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Staphylococcus aureus PDF by absorbance detection assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Staphylococcus aureus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Peptide deformylase (CHEMBL2010635)
Type SINGLE PROTEIN
Organism Staphylococcus aureus

Publication

Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections.
Spletstoser JT, Dreabit J, Knox AN, Benowitz A, Campobasso N, Ward P, Cui G, Lewandowski T, McCloskey L, Aubart KM.
Bioorg Med Chem Lett (2019) 29 : 2410 -2414
PubMed 31160176 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 8.51 9.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4458398 1 9.20
CHEMBL4462876 1 9.00
CHEMBL4457234 1 9.00
CHEMBL4568739 1 8.70
CHEMBL4466084 1 8.70
CHEMBL4434997 1 8.70
CHEMBL4448951 1 8.70
CHEMBL4435970 1 8.30
CHEMBL4437963 1 8.22
CHEMBL4440847 1 7.96
CHEMBL3301608 LANOPEPDEN 2.0 1 7.92
CHEMBL4471518 1 7.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4458398 IC50 = 0.63 nM 9.20
CHEMBL4462876 IC50 = 1.0 nM 9.00
CHEMBL4457234 IC50 = 1.0 nM 9.00
CHEMBL4568739 IC50 = 2.0 nM 8.70
CHEMBL4466084 IC50 = 2.0 nM 8.70
CHEMBL4434997 IC50 = 2.0 nM 8.70
CHEMBL4448951 IC50 = 2.0 nM 8.70
CHEMBL4435970 IC50 = 5.0 nM 8.30
CHEMBL4437963 IC50 = 6.0 nM 8.22
CHEMBL4440847 IC50 = 11.0 nM 7.96
CHEMBL3301608 LANOPEPDEN IC50 = 12.0 nM 7.92
CHEMBL4471518 IC50 = 18.0 nM 7.75