Assay Detail
Binding
CHEMBL4434146
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Inhibition of Streptococcus pneumoniae PDF by fluorescence detection assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Streptococcus pneumoniae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.72 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4572153 | — | — | 1 | 9.52 |
| CHEMBL4559778 | — | — | 1 | 9.40 |
| CHEMBL4518477 | — | — | 1 | 9.22 |
| CHEMBL4447270 | — | — | 1 | 9.10 |
| CHEMBL4565584 | — | — | 1 | 9.00 |
| CHEMBL4454464 | — | — | 1 | 8.70 |
| CHEMBL4547624 | — | — | 1 | 8.10 |
| CHEMBL4435803 | — | — | 1 | 8.00 |
| CHEMBL4474270 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4572153 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4559778 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4518477 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4447270 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL4565584 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4454464 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4547624 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4435803 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4474270 | — | IC50 | = | 40.0 | nM | 7.40 |