Assay Detail
Binding
CHEMBL4434176
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant GST-tagged human full length CDK14/cyclin Y (2 to end residues) preincubated for 30 mins by Lantha screen eu binding assay
100
Total Activities
100
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 14/Cyclin-Y (CHEMBL4296115) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 100 | 7.21 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4563703 | — | — | 1 | 9.40 |
| CHEMBL4535078 | — | — | 1 | 9.10 |
| CHEMBL4446451 | — | — | 1 | 8.80 |
| CHEMBL4522598 | — | — | 1 | 8.74 |
| CHEMBL4515515 | — | — | 1 | 8.59 |
| CHEMBL4530961 | — | — | 1 | 8.52 |
| CHEMBL4542127 | — | — | 1 | 8.52 |
| CHEMBL4527767 | — | — | 1 | 8.47 |
| CHEMBL4579572 | — | — | 1 | 8.19 |
| CHEMBL4519165 | — | — | 1 | 8.00 |
| CHEMBL4456492 | — | — | 1 | 7.96 |
| CHEMBL4563705 | — | — | 1 | 7.85 |
| CHEMBL4459422 | — | — | 1 | 7.85 |
| CHEMBL4555069 | — | — | 1 | 7.77 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 7.70 |
| CHEMBL4589122 | — | — | 1 | 7.57 |
| CHEMBL4473682 | — | — | 1 | 7.47 |
| CHEMBL4584359 | — | — | 1 | 7.39 |
| CHEMBL4554744 | — | — | 1 | 7.35 |
| CHEMBL4576258 | — | — | 1 | 7.35 |
| CHEMBL4544087 | — | — | 1 | 7.32 |
| CHEMBL4474689 | — | — | 1 | 7.31 |
| CHEMBL4464758 | — | — | 1 | 7.30 |
| CHEMBL4586749 | — | — | 1 | 7.21 |
| CHEMBL4583677 | — | — | 1 | 7.17 |
| CHEMBL4466362 | — | — | 1 | 7.14 |
| CHEMBL4459085 | — | — | 1 | 7.11 |
| CHEMBL4447871 | — | — | 1 | 7.09 |
| CHEMBL4466865 | — | — | 1 | 7.09 |
| CHEMBL4556640 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4563703 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4535078 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4446451 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4522598 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4515515 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4530961 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4542127 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4527767 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4579572 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4519165 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4456492 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4563705 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4459422 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4555069 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL445813 | AT-7519 | IC50 | = | 19.8 | nM | 7.70 |
| CHEMBL4589122 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4473682 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4584359 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4554744 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4576258 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4544087 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4474689 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4464758 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4586749 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4583677 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4466362 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4459085 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4447871 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4466865 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4556640 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4435761 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4434727 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4536978 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4561411 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL4444448 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4531892 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL4439068 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL4461471 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL4461838 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL4570828 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL4468007 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL4464414 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL4527939 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL4459908 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL4453025 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL4446588 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL4453129 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL4447917 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL4451930 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL4543386 | — | IC50 | = | 332.0 | nM | 6.48 |