Assay Detail
Functional
CHEMBL4476913
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxic activity against human NCI-H2171 cells assessed as reduction in cell viability incubated for 3 days by ATPlite assay
136
Total Activities
136
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2171 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrrol-1-yl benzoic acid derivatives useful as myc inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 136 | 5.25 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4557073 | — | — | 1 | 9.30 |
| CHEMBL4540324 | — | — | 1 | 9.26 |
| CHEMBL4560633 | — | — | 1 | 8.59 |
| CHEMBL4588527 | — | — | 1 | 8.59 |
| CHEMBL4514651 | — | — | 1 | 8.44 |
| CHEMBL375971 | — | — | 1 | 8.28 |
| CHEMBL4515363 | — | — | 1 | 6.25 |
| CHEMBL4583973 | — | — | 1 | 6.04 |
| CHEMBL4587202 | — | — | 1 | 5.99 |
| CHEMBL4556647 | — | — | 1 | 5.98 |
| CHEMBL4522087 | — | — | 1 | 5.92 |
| CHEMBL4538098 | — | — | 1 | 5.65 |
| CHEMBL4537401 | — | — | 1 | 5.62 |
| CHEMBL4529028 | — | — | 1 | 5.55 |
| CHEMBL4570098 | — | — | 1 | 5.20 |
| CHEMBL4571749 | — | — | 1 | 4.68 |
| CHEMBL4554119 | — | — | 1 | 4.64 |
| CHEMBL4544865 | — | — | 1 | 4.62 |
| CHEMBL4558120 | — | — | 1 | 4.55 |
| CHEMBL4533461 | — | — | 1 | 4.49 |
| CHEMBL4534756 | — | — | 1 | 4.47 |
| CHEMBL4513566 | — | — | 1 | 4.42 |
| CHEMBL4520735 | — | — | 1 | 4.37 |
| CHEMBL4527497 | — | — | 1 | 4.36 |
| CHEMBL4536775 | — | — | 1 | 4.32 |
| CHEMBL4588003 | — | — | 1 | 4.28 |
| CHEMBL4549559 | — | — | 1 | 4.26 |
| CHEMBL1559731 | — | — | 1 | 4.22 |
| CHEMBL4579136 | — | — | 1 | 4.19 |
| CHEMBL4541426 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4557073 | — | EC50 | = | 0.502 | nM | 9.30 |
| CHEMBL4540324 | — | EC50 | = | 0.553 | nM | 9.26 |
| CHEMBL4560633 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4588527 | — | EC50 | = | 2.59 | nM | 8.59 |
| CHEMBL4514651 | — | EC50 | = | 3.63 | nM | 8.44 |
| CHEMBL375971 | — | EC50 | = | 5.31 | nM | 8.28 |
| CHEMBL4515363 | — | EC50 | = | 556.0 | nM | 6.25 |
| CHEMBL4583973 | — | EC50 | = | 913.0 | nM | 6.04 |
| CHEMBL4587202 | — | EC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4556647 | — | EC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL4522087 | — | EC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4538098 | — | EC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL4537401 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4529028 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4570098 | — | EC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL4571749 | — | EC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL4554119 | — | EC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL4544865 | — | EC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL4558120 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4533461 | — | EC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL4534756 | — | EC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL4513566 | — | EC50 | = | 38100.0 | nM | 4.42 |
| CHEMBL4520735 | — | EC50 | = | 42700.0 | nM | 4.37 |
| CHEMBL4527497 | — | EC50 | = | 43500.0 | nM | 4.36 |
| CHEMBL4536775 | — | EC50 | = | 48400.0 | nM | 4.32 |
| CHEMBL4588003 | — | EC50 | = | 52900.0 | nM | 4.28 |
| CHEMBL4549559 | — | EC50 | = | 54400.0 | nM | 4.26 |
| CHEMBL1559731 | — | EC50 | = | 60600.0 | nM | 4.22 |
| CHEMBL4579136 | — | EC50 | = | 64900.0 | nM | 4.19 |
| CHEMBL4541426 | — | EC50 | = | 67900.0 | nM | 4.17 |
| CHEMBL4528956 | — | EC50 | = | 70300.0 | nM | 4.15 |
| CHEMBL4562176 | — | EC50 | = | 73400.0 | nM | 4.13 |
| CHEMBL387115 | — | EC50 | = | 76300.0 | nM | 4.12 |
| CHEMBL4569331 | — | EC50 | = | 83800.0 | nM | 4.08 |
| CHEMBL4520816 | — | EC50 | = | 84100.0 | nM | 4.08 |
| CHEMBL4558024 | — | EC50 | = | 86300.0 | nM | 4.06 |
| CHEMBL4584112 | — | EC50 | = | 89100.0 | nM | 4.05 |
| CHEMBL686 | MEFENAMIC ACID | EC50 | = | 93500.0 | nM | 4.03 |
| CHEMBL4541510 | — | EC50 | = | 96400.0 | nM | 4.02 |
| CHEMBL4545975 | — | EC50 | = | 97300.0 | nM | 4.01 |
| CHEMBL1332168 | — | EC50 | = | 96900.0 | nM | 4.01 |
| CHEMBL4580673 | — | EC50 | - | — | - | |
| CHEMBL4549129 | — | EC50 | = | 3240000.0 | nM | - |
| CHEMBL4553728 | — | EC50 | - | — | - | |
| CHEMBL4593257 | — | EC50 | - | — | - | |
| CHEMBL4531825 | — | EC50 | = | 24100000.0 | nM | - |
| CHEMBL4564509 | — | EC50 | - | — | - | |
| CHEMBL4584499 | — | EC50 | = | 106000.0 | nM | - |
| CHEMBL4534256 | — | EC50 | = | 266000.0 | nM | - |
| CHEMBL4544077 | — | EC50 | - | — | - |