Assay Detail
Functional
CHEMBL4476914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxic activity against human MM1S cells assessed as reduction in cell viability incubated for 3 days by ATPlite assay
136
Total Activities
136
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MM1.S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrrol-1-yl benzoic acid derivatives useful as myc inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 136 | 4.85 | 10.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4554011 | — | — | 1 | 10.84 |
| CHEMBL4580874 | — | — | 1 | 10.40 |
| CHEMBL4549129 | — | — | 1 | 5.24 |
| CHEMBL4556647 | — | — | 1 | 5.03 |
| CHEMBL4587202 | — | — | 1 | 5.00 |
| CHEMBL4529028 | — | — | 1 | 4.96 |
| CHEMBL4570098 | — | — | 1 | 4.94 |
| CHEMBL4522087 | — | — | 1 | 4.93 |
| CHEMBL4583973 | — | — | 1 | 4.87 |
| CHEMBL4538098 | — | — | 1 | 4.83 |
| CHEMBL4537401 | — | — | 1 | 4.66 |
| CHEMBL4534756 | — | — | 1 | 4.62 |
| CHEMBL4515996 | — | — | 1 | 4.41 |
| CHEMBL4571749 | — | — | 1 | 4.28 |
| CHEMBL4586334 | — | — | 1 | 4.28 |
| CHEMBL4579136 | — | — | 1 | 4.24 |
| CHEMBL4544865 | — | — | 1 | 4.18 |
| CHEMBL4549559 | — | — | 1 | 4.16 |
| CHEMBL4562176 | — | — | 1 | 4.14 |
| CHEMBL4554119 | — | — | 1 | 4.14 |
| CHEMBL4584112 | — | — | 1 | 4.12 |
| CHEMBL1434012 | — | — | 1 | 4.11 |
| CHEMBL1333409 | — | — | 1 | 4.10 |
| CHEMBL4513253 | — | — | 1 | 4.08 |
| CHEMBL4560663 | — | — | 1 | 4.06 |
| CHEMBL4567078 | — | — | 1 | 4.03 |
| CHEMBL4549833 | — | — | 1 | 4.01 |
| CHEMBL4520735 | — | — | 1 | 4.00 |
| CHEMBL4558120 | — | — | 1 | 4.00 |
| CHEMBL1332168 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4554011 | — | EC50 | = | 0.0146 | nM | 10.84 |
| CHEMBL4580874 | — | EC50 | = | 0.0395 | nM | 10.40 |
| CHEMBL4549129 | — | EC50 | = | 5750.0 | nM | 5.24 |
| CHEMBL4556647 | — | EC50 | = | 9250.0 | nM | 5.03 |
| CHEMBL4587202 | — | EC50 | = | 9990.0 | nM | 5.00 |
| CHEMBL4529028 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4570098 | — | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4522087 | — | EC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4583973 | — | EC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL4538098 | — | EC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL4537401 | — | EC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL4534756 | — | EC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL4515996 | — | EC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL4571749 | — | EC50 | = | 52300.0 | nM | 4.28 |
| CHEMBL4586334 | — | EC50 | = | 52500.0 | nM | 4.28 |
| CHEMBL4579136 | — | EC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL4544865 | — | EC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL4549559 | — | EC50 | = | 69900.0 | nM | 4.16 |
| CHEMBL4562176 | — | EC50 | = | 71700.0 | nM | 4.14 |
| CHEMBL4554119 | — | EC50 | = | 71900.0 | nM | 4.14 |
| CHEMBL4584112 | — | EC50 | = | 75300.0 | nM | 4.12 |
| CHEMBL1434012 | — | EC50 | = | 78300.0 | nM | 4.11 |
| CHEMBL1333409 | — | EC50 | = | 79300.0 | nM | 4.10 |
| CHEMBL4513253 | — | EC50 | = | 83200.0 | nM | 4.08 |
| CHEMBL4560663 | — | EC50 | = | 86500.0 | nM | 4.06 |
| CHEMBL4567078 | — | EC50 | = | 92400.0 | nM | 4.03 |
| CHEMBL4549833 | — | EC50 | = | 98500.0 | nM | 4.01 |
| CHEMBL4558120 | — | EC50 | = | 99100.0 | nM | 4.00 |
| CHEMBL4520735 | — | EC50 | = | 99100.0 | nM | 4.00 |
| CHEMBL686 | MEFENAMIC ACID | EC50 | = | 185000.0 | nM | - |
| CHEMBL1556162 | — | EC50 | = | 148000.0 | nM | - |
| CHEMBL4573457 | — | EC50 | = | 1690000.0 | nM | - |
| CHEMBL4527497 | — | EC50 | = | 156000.0 | nM | - |
| CHEMBL4515363 | — | EC50 | - | — | - | |
| CHEMBL4533461 | — | EC50 | - | — | - | |
| CHEMBL4561825 | — | EC50 | - | — | - | |
| CHEMBL4550118 | — | EC50 | = | 118000.0 | nM | - |
| CHEMBL4544077 | — | EC50 | - | — | - | |
| CHEMBL4565626 | — | EC50 | - | — | - | |
| CHEMBL4593257 | — | EC50 | - | — | - | |
| CHEMBL4534256 | — | EC50 | - | — | - | |
| CHEMBL4584499 | — | EC50 | = | 492000.0 | nM | - |
| CHEMBL4531825 | — | EC50 | = | 5170000.0 | nM | - |
| CHEMBL4564509 | — | EC50 | = | 1040000.0 | nM | - |
| CHEMBL4513566 | — | EC50 | - | — | - | |
| CHEMBL4553728 | — | EC50 | - | — | - | |
| CHEMBL4540324 | — | EC50 | = | 263000.0 | nM | - |
| CHEMBL4588527 | — | EC50 | = | 731000.0 | nM | - |
| CHEMBL4551980 | — | EC50 | = | 4260000.0 | nM | - |
| CHEMBL4580673 | — | EC50 | - | — | - |