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Assay Detail

CHEMBL4477003

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human PC14 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
ChEMBL ↗
222
Total Activities
222
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PC-14
Confidence 1 — Organism
Curated By Autocuration

Target

PC-14 (CHEMBL614140) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Bicyclic compound and use thereof for inhibiting suv39h2
(2018)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 222 5.60 7.23

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4587622 — — 1 7.23
CHEMBL4590206 — — 1 6.62
CHEMBL4526470 — — 1 6.42
CHEMBL4584921 — — 1 6.35
CHEMBL4554238 — — 1 6.33
CHEMBL4564150 — — 1 6.29
CHEMBL4513384 — — 1 6.24
CHEMBL4575521 — — 1 6.22
CHEMBL4542019 — — 1 6.21
CHEMBL4529303 — — 1 6.21
CHEMBL4573508 — — 1 6.20
CHEMBL4541772 — — 1 6.19
CHEMBL4525814 — — 1 6.17
CHEMBL4574823 — — 1 6.17
CHEMBL4555676 — — 1 6.16
CHEMBL4535905 — — 1 6.16
CHEMBL4583709 — — 1 6.15
CHEMBL4541065 — — 1 6.14
CHEMBL4593686 — — 1 6.13
CHEMBL4572381 — — 1 6.13
CHEMBL4559621 — — 1 6.12
CHEMBL4541514 — — 1 6.11
CHEMBL4585854 — — 1 6.10
CHEMBL4553425 — — 1 6.10
CHEMBL4565632 — — 1 6.10
CHEMBL4579951 — — 1 6.10
CHEMBL4519747 — — 1 6.06
CHEMBL4558804 — — 1 6.06
CHEMBL4555239 — — 1 6.06
CHEMBL4586890 — — 1 6.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4587622 — IC50 = 59.0 nM 7.23
CHEMBL4590206 — IC50 = 240.0 nM 6.62
CHEMBL4526470 — IC50 = 380.0 nM 6.42
CHEMBL4584921 — IC50 = 450.0 nM 6.35
CHEMBL4554238 — IC50 = 470.0 nM 6.33
CHEMBL4564150 — IC50 = 510.0 nM 6.29
CHEMBL4513384 — IC50 = 570.0 nM 6.24
CHEMBL4575521 — IC50 = 600.0 nM 6.22
CHEMBL4529303 — IC50 = 610.0 nM 6.21
CHEMBL4542019 — IC50 = 620.0 nM 6.21
CHEMBL4573508 — IC50 = 630.0 nM 6.20
CHEMBL4541772 — IC50 = 640.0 nM 6.19
CHEMBL4574823 — IC50 = 680.0 nM 6.17
CHEMBL4525814 — IC50 = 680.0 nM 6.17
CHEMBL4555676 — IC50 = 700.0 nM 6.16
CHEMBL4535905 — IC50 = 700.0 nM 6.16
CHEMBL4583709 — IC50 = 710.0 nM 6.15
CHEMBL4541065 — IC50 = 730.0 nM 6.14
CHEMBL4593686 — IC50 = 740.0 nM 6.13
CHEMBL4572381 — IC50 = 740.0 nM 6.13
CHEMBL4559621 — IC50 = 750.0 nM 6.12
CHEMBL4541514 — IC50 = 770.0 nM 6.11
CHEMBL4585854 — IC50 = 800.0 nM 6.10
CHEMBL4553425 — IC50 = 800.0 nM 6.10
CHEMBL4579951 — IC50 = 790.0 nM 6.10
CHEMBL4565632 — IC50 = 800.0 nM 6.10
CHEMBL4555239 — IC50 = 880.0 nM 6.06
CHEMBL4519747 — IC50 = 880.0 nM 6.06
CHEMBL4558804 — IC50 = 870.0 nM 6.06
CHEMBL4586890 — IC50 = 900.0 nM 6.05
CHEMBL4579974 — IC50 = 930.0 nM 6.03
CHEMBL4526034 — IC50 = 940.0 nM 6.03
CHEMBL4561677 — IC50 = 930.0 nM 6.03
CHEMBL4570591 — IC50 = 940.0 nM 6.03
CHEMBL4571602 — IC50 = 950.0 nM 6.02
CHEMBL4579876 — IC50 = 960.0 nM 6.02
CHEMBL4526344 — IC50 = 980.0 nM 6.01
CHEMBL4583879 — IC50 = 980.0 nM 6.01
CHEMBL4556415 — IC50 = 990.0 nM 6.00
CHEMBL4591418 — IC50 = 1000.0 nM 6.00
CHEMBL4581193 — IC50 = 1000.0 nM 6.00
CHEMBL4546280 — IC50 = 1000.0 nM 6.00
CHEMBL4559113 — IC50 = 990.0 nM 6.00
CHEMBL4520199 — IC50 = 1100.0 nM 5.96
CHEMBL4550422 — IC50 = 1100.0 nM 5.96
CHEMBL4557658 — IC50 = 1200.0 nM 5.92
CHEMBL4483497 — IC50 = 1200.0 nM 5.92
CHEMBL4550153 — IC50 = 1300.0 nM 5.89
CHEMBL4515454 — IC50 = 1300.0 nM 5.89
CHEMBL4543316 — IC50 = 1300.0 nM 5.89