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Assay Detail

CHEMBL4477289

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]PDBu binding to recombinant full length human PKCdelta expressed in baculovirus expression system incubated for 5 mins by scintillation counting method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Protein kinase C delta type (CHEMBL2996)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway.
Staveness D, Abdelnabi R, Near KE, Nakagawa Y, Neyts J, Delang L, Leyssen P, Wender PA.
J Nat Prod (2016) 79 : 680 -684
PubMed 26900711 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 7.99 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL449158 BRYOSTATIN 1 2.0 1 8.96
CHEMBL4565484 1 8.89
CHEMBL4533216 1 8.72
CHEMBL4574406 1 8.57
CHEMBL4593581 1 8.55
CHEMBL4536091 1 8.48
CHEMBL4526756 1 8.47
CHEMBL4576842 1 8.44
CHEMBL4525186 1 8.40
CHEMBL4574986 1 8.36
CHEMBL4550131 1 8.29
CHEMBL4542079 1 8.23
CHEMBL4560593 1 8.12
CHEMBL4535813 1 8.10
CHEMBL4564420 1 8.04
CHEMBL4519769 1 7.92
CHEMBL4541641 1 7.75
CHEMBL4559327 1 7.55
CHEMBL4575057 1 6.06
CHEMBL4212128 1 6.00
CHEMBL4482943 1 5.92
CHEMBL4550478 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL449158 BRYOSTATIN 1 Ki = 1.1 nM 8.96
CHEMBL4565484 Ki = 1.3 nM 8.89
CHEMBL4533216 Ki = 1.9 nM 8.72
CHEMBL4574406 Ki = 2.7 nM 8.57
CHEMBL4593581 Ki = 2.8 nM 8.55
CHEMBL4536091 Ki = 3.3 nM 8.48
CHEMBL4526756 Ki = 3.4 nM 8.47
CHEMBL4576842 Ki = 3.6 nM 8.44
CHEMBL4525186 Ki = 4.0 nM 8.40
CHEMBL4574986 Ki = 4.4 nM 8.36
CHEMBL4550131 Ki = 5.1 nM 8.29
CHEMBL4542079 Ki = 5.9 nM 8.23
CHEMBL4560593 Ki = 7.6 nM 8.12
CHEMBL4535813 Ki = 7.9 nM 8.10
CHEMBL4564420 Ki = 9.1 nM 8.04
CHEMBL4519769 Ki = 12.0 nM 7.92
CHEMBL4541641 Ki = 18.0 nM 7.75
CHEMBL4559327 Ki = 28.0 nM 7.55
CHEMBL4575057 Ki = 880.0 nM 6.06
CHEMBL4212128 Ki = 1000.0 nM 6.00
CHEMBL4482943 Ki = 1200.0 nM 5.92
CHEMBL4550478 Ki > 250.0 nM -